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Correlates of PLMs variability over multiple nights and impact upon RLS diagnosis.

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It has similar side effects to the other dopamine agonist.

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Our data indicate that pramipexole improves depressive symptoms in patients with Parkinson's disease.

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As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

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Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening (augmentation) of RLS with long-term treatment.

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The current study was supported by the Parkinson's Disease Foundation.

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Every patient who had not received amantadine prior to referral to the author was given that medication during the course of the present observation period.

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Because these two populations may have differential risks for various adverse reactions, this section will, in general, present adverse-reaction data for these two populations separately.

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Although not reported with pramipexole in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in dopaminergic therapy.

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If medications may be causing RLS, the doctor should try to prescribe alternatives, if possible.

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The use of simvastatin was associated with a reduction in incident dementia; and after adjusting for cardiovascular disease, hypertension, diabetes and the use of neuroleptics, simvastatin was also observed to be associated with a reduced incidence of PD ().

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