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This remains an important question that warrants study in a larger cohort.
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Correlates of PLMs variability over multiple nights and impact upon RLS diagnosis.
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Pramipexole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Yes, this antibody identifies dopaminergic axons and nerve ending during early mouse, rat and human development.
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Western medicine over the next two centuries into that of a debilitating illness.
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DESIGN: A case-control study of echocardiographic findings of valve function in patients receiving dopamine agonists for PD.
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Recommend it to my mother for her restless legs and she was so surprised at how well it worked.
It has similar side effects to the other dopamine agonist.
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Then it slowly lost its effectiveness.
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It was independently described first in 1905 by Zappert as jactatio capitis nocturna and by Cruchet as rhythmie du sommeil.
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FDA evaluated a pooled analysis of randomized clinical trials and found that heart failure was more frequent with pramipexole than with placebo; however, these results were not statistically significant.
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Our data indicate that pramipexole improves depressive symptoms in patients with Parkinson's disease.
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Awful medicine due to side effects and extreme difficulty to stop it: no benefits for the patient, as far as I could see.
Tramadol not to sure of that drug so I am not able to comment on that one.
Nevertheless, antidepressants should be used with caution in children with RLS and PLMS, and other potential therapeutic agents described above should be explored in comorbid mental disorders and sleep-related movement disorders.
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Depression severity was assessed with the Hamilton Depression Rating Scale 21-item version (HDRS-21).
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As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.
Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from MIRAPEX, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
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Sedatives may have an additive effect when prescribed to patients who are taking antiparkinsonian drugs.
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Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have the potential to cause iatrogenic worsening (augmentation) of RLS with long-term treatment.
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Pramipexole was otherwise well tolerated with side effects including mild nausea and fatigue.
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The current study was supported by the Parkinson's Disease Foundation.
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Every patient who had not received amantadine prior to referral to the author was given that medication during the course of the present observation period.
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Medication trials have included: baclofen, tizanidine, dantrolene, trihexyphenidyl, benzotropine, levodopa, pramipexole, ropinirole, botulinum toxins A and B, and tetrabenzine via compassionate use protocol.
Chronic desipramine treatment in rats decreased the sensitivity of α 2-adrenoceptors, a finding supported by the fact that clonidine administration caused a significant increase in growth hormone (an indirect measure of α 2-adrenoceptor activity) although platelet studies proved inconsistent.
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Because these two populations may have differential risks for various adverse reactions, this section will, in general, present adverse-reaction data for these two populations separately.
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Although not reported with pramipexole in the clinical development program, a symptom complex resembling the neuroleptic malignant syndrome (characterized by elevated temperature, muscular rigidity, altered consciousness, and autonomic instability), with no other obvious etiology, has been reported in association with rapid dose reduction, withdrawal of, or changes in dopaminergic therapy.
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If medications may be causing RLS, the doctor should try to prescribe alternatives, if possible.
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The use of simvastatin was associated with a reduction in incident dementia; and after adjusting for cardiovascular disease, hypertension, diabetes and the use of neuroleptics, simvastatin was also observed to be associated with a reduced incidence of PD ().
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